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The Liver Biology and Pathobiology FIFTH EDITION Irwin M. Arias, Harvey J. Alter, James L. Boyer, David E. Cohen, Nelson Fausto, David A. Shafritz, Allen W. Wollkof

This brand new edition of The Liver: Biology and Pathobiology will once again serve as the premier textbook of basic science hepatology.

By exploring the advances in genetics, immunology, chemistry, virology, biophysics, and structural, molecular and cellular biology, this textbook will help improve understanding of liver function and the nature of liver disease.

With emphasis placed on the impact of genomics, proteomics, combinatorial chemistry, micro-imaging, stem cell biology, and other advances in basic biology on hepatology, the book will be a useful tool for all those interested in the diagnosis, treatment, and prevention of liver disease.

Clearly structured, each chapter is organized around six major headings: Introduction (organizational principles of the liver and embryology), The Cells, Interrelated cell functions, Relation to other organs, Pathobiologic analysis, Horizons.

With an outstanding editorial team who have brought together an internationally recognized collection of contributors, The Liver: Biology and Pathobiology will continue the tradition of previous editions in effectively bridging the many advances in basic science with mechanisms of liver function and disease.

As such, it will be essential reading for basic and clinical scientists, PhD students and fellows, and academic physicians interested in the study of the liver.

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Sample Chapters

Select a chapter from the list below, to see free sample chapters from the previous editions. (All chapters are in PDF format.)

• Apoptosis: Mechanisms and Relevance in Liver Diseases – Fifth Edition
  Harmeet Malhi, Gregory J. Gores

• 5. Gene regulation and in vivo function of liver transcription factors – Fourth Edition
  Robert H. Costa, AI-Xuan Le Holternan, Francisco M. Rausa, Guy R. Adami

• 16. Energy Metabolism – Third Edition

• 18. Hypoxic, Ischemic and reperfusion injury to liver – Fourth Edition
  John J. Lemasters

• 19. Protective mechanisms against reactive oxygen species – Fourth Edition
  Masayasu Inoue

• 20. Disorders of bilirubin metabolism – Fourth Edition
  Namita Roy Chowdhury, Irwin M. Arias, Allan W. Wolkoff, Jayanta Roy Chowdhury

• 21. The porphyrias – Fourth Edition
  Peter N. Meissner, Richard J. Hift, Ralph E. Kirsch

• 27. Hormonal regulation of bile secretion – Fourth Edition
  Francis R. Simon

• 28. Nucleotide transport and regulation of bile formation – Fourth Edition
  Richard M. Roman and J. Gregory Fitz

• 30. Endothelial and pit cells – Fourth Edition
  Filip Braet, Dianzhong Luo, Ilan Spector, David Vermijlen, Eddie Wisse

• 35 Synthesis of and signalling through D-3 phosphoinositides – Fourth Edition
  Rial A Christensen, Isabel De Aos Scherpenseel, Lyuba Varticovski

• 38. Ca2+ signaling in the liver – Fourth Edition
  Maria De Fatima Leite, Michael H. Nathanson

• 39. Nitric oxide in the liver – Fourth Edition
  Mark G. Clemens

• 40. Interleukin-6 signaling during the acute-phase response of the liver – Fourth Edition
  Johannes G. Bode, Peter C. Heinrich

• 41. Innate immune sensing and the toll-like receptors – Fourth Edition
  Bruce Beutler

• 42. Liver regeneration – Fourth Edition
  Nelson Fausto

• 43. Hepatocyte growth factor: its role in hepatic growth and pathobiology – Fourth Edition
  Reza Zarnegar, Marie C. Defrances, George K. Michalopoulos

• 48. Alpha 1-Antitrypsin deficiency – Fourth Edition
  David H. Perlmutter

• 63. Novel strategies for manipulating hepatic gene expression in vivo – Fourth Edition
  Marxa L. Figueiredo, Eric P. Sandgren